A Secret Weapon For https://www.ceesdekker.net
A Secret Weapon For https://www.ceesdekker.net
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Human Rad51 filaments on double- and one-stranded DNA: correlating typical and irregular sorts with recombination perform.
Dynamics of initiation, termination and reinitiation of DNA translocation by the motor protein EcoR124I
Considering that 2000, Dekker has shifted the main target of his get the job done towards biophysics the place he studies the Qualities of solitary biomolecules and cells utilizing the applications of nanotechnology. This transformation of subject was pushed by his fascination for the exceptional operating of Organic molecular buildings, as well as from the prolonged-expression standpoint that numerous fascinating discoveries could be anticipated In this particular subject.[five] Present-day strains of research in his biophysics group are while in the regions of:[six]
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The coiled-coil with the human Rad50 DNA fix protein contains precise segments of improved adaptability
MATLAB codes for details processing can be obtained at . Julia codes utilized for numerical simulation are offered at .
He also located time to jot down numerous guides, deliver Pretty much forty thousand tweets and lead An effective research group at Delft College of Technologies. ‘It doesn’t come to feel like work’, he states. ‘I’m just terribly curious.’
In 1993, as a young and eager affiliate professor at Delft College of Technologies, I'd initially targeted the exploration endeavours of my group on measuring the electrical conductance of just one conducting-polymer molecule. Within just two decades, we had developed a device where only one wire of a phthalocyaninepolysiloxane polymer was connected amongst two carefully spaced metallic nanoelectrodes.
At this time, we also understood that it ought to be doable to implement one semiconducting carbon nanotube to generate a transistor — and we set out to make it. We stretched personal semiconducting nanotubes throughout metallic electrodes and made use of the fundamental silicon substrate for a gate electrode, developing The fundamental three-terminal structure of the discipline-result transistor (Fig.
Illustration (4) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is shown in gray, the rim with the pore is highlighted in purple, as well as a 3D rendering from the movement with the DNA rod is shown.
Afterwards we spoke once again briefly for the reason that Dekker felt that our dialogue of his faith rapidly grew to become purely philosophical, While In addition it concretely helps him in his function.
Visualization of unstained DNA nanostructures with State-of-the-art in-aim transmission electron https://www.ceesdekker.net microscopy techniques
Stable-point out nanopores have demonstrated to generally be a shockingly multipurpose probe for one-molecule Assessment of DNA. I'll explain a number of our modern results – especially DNA knots – along with our attempts to increase the capabilities of sound-state nanopores even further, in the direction of one-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.